Superseded - see the FAQ category for the most up to date version.
To make things a little easier for people coming here for the first time, I have updated my brief list of posts which readers may find helpful. Regular readers (and anyone else for that matter) may wish to point out any useful items I may inadvertently have omitted (just post a comment).
Innovation: This list is getting long, so I have attempted to indicate the more generally useful posts by means of a star rating like so: 
Post a comment if you like it, don't like it or disagree with any of the ratings.
Another reason not to use port 25 for message submission
Count your MXes
SMTP fixup
Superstition (garlic, silver bullets, disclaimers)
To block or not to block...
Unintended consequences - Backscatter vectors
When should a machine respond to email?
Gmail, spam and blacklisting
Recommended DNSBLs
What port do I need to open for DNSBL queries?
postmaster@, domain literal, RFC compliance...
220 too much information
A Domino Anti-Spam Architecture
Domino server - Rejecting spam at the protocol level
Domino Server: SMTP Stats - part 1
Enforcing a local Domino sender policy
Setting up Domino SMTP TLS
Setting up and testing DNSBLs in Domino 6.x
SMTP Server: mail.example.com (192.168.0.1) disconnected. 0 message[s] received
Some recommended server configuration settings
Multiple SSL sites, single Domino server
Why GZip is disabled in D7
Avoid Domino 4.6 as an SMTP server
Identifying DNSBL false positives
SMTP and Internet Site documents in D7
SMTP Server: Authentication is not enabled in the SMTP Internet Site Document for...
Get ready for the ND7 whitelist
Populating your whitelist using Pareto analysis
Enhanced Mail Rules on D7
Free for a limited time
Getting started with enhanced mail rules
How to reject backscatter
How to lay low an entire email community
Spam proxies and back doors
You need spam
Unsafe at any speed
How to prevent SMTP AUTH abuse
Quarantining unknown malware
Rejecting Netsky at source (554)
Some file types commonly found in email and what to do about them
Virus Stubs, Domino and Trend SMD3
1. Jack Dausman04/05/2006 22:34:50
Homepage: http://WWW.leadershipbynumbers.com
Fantastic. I realize it took some time to compile and rank your material. I'll be sure to point this doc out to all the admins with whom I work.
2. Martin Gautier28/11/2006 19:23:01
Homepage: http://www.fearofmice.co.uk
Excellent. I've just started needing to manage my own spam after finding my new ISP won't do it for me. These links have saved me a huge bunch of time.
Cheers!
3. Sjef Bosman15/12/2006 09:48:24
I think kSpam now deserves its own link on the page above.
http://www.openntf.org/Projects/pmt.nsf/ProjectHome?ReadForm&Query=kSpam
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